General FIT Resources

Faecal Immunochemical Tests for Haemoglobin: Analytical Challenges and Potential Solutions

There are a number of analytical challenges including preanalytical variation, difficulty setting up external quality assessment schemes, access to third party internal quality control material and a lack of standardisation or harmonisation of FIT methods.

Benton, S. C., et. al. (2021) Clinica Chimica Acta.
Systematic review with meta-analysis: volatile organic compound analysis to improve faecal immunochemical testing in the detection of colorectal cancer

In a FIT-negative symptomatic population, VOC can be a good test to rule-out the presence of CRC. The estimated probability reduction by 0.4% when both tests being negative offers adequate safety netting in primary care for the exclusion of CRC. The number needed to colonoscope to identify one CRC is eight if either FIT or VOC positive. Cost-effectiveness and clinical accuracy of this approach will need further evaluation.

Chandrapalan, S. (2021)  Alimentary Pharmacology & Therapeutics. DOI: 10.1111/apt.16405 
Use of ColonFlag score for prioritisation of endoscopy in colorectal cancer

This study showed ColonFlag to have equal sensitivity and greater specificity than f-Hb at a cut-off of 10 μg/g as a triage tool for CRC

Ayling RM, Wong A, Cotter F. BMJ Open Gastro 2021;8:e000639. doi:10.1136/bmjgast-2021-000639