HM-JACKarc uses Integrated Sphere Latex Turbidimetry to measure faecal haemoglobin concentration. The EXTEL HEMO-AUTO HS Latex reagent is composed of consistently sized latex particles. Polyclonal antibodies, specific for human haemoglobin, are bound to the surface of the latex in high concentrations to ensure a very high antigen capture ratio and provide a highly sensitive reagent.
The latex particles have an excess of antibodies to provide a system that will have a hook capacity greater than 200,000ng/ml of haemoglobin (equivalent to 200,000 µg of Hb/g faeces).
This achieves two key benefits:
A wide linear dynamic assay range (7µg Hb/g faeces to 400µg Hb/g faeces)
A very high hook capacity (200,000 µg Hb/g of faeces) so that it still generates a result for samples higher than the top standard, ensuring no patient is given an artificially low result
Latex Reagent
Provides a large concentration of capture antibodies
Wide linear dynamic range
7ng/ml to 400 ng/ml (ng/ml = µg Hb/g faeces)
High Hook capacity > 200,000ng/ml
Ensures no samples will give a falsely lower result
Drives reaction kinetics to end stage equilibrium quickly
Each lot of reagent has a factory set reaction response master curve. This is confirmed by performing a local 2 point recalibration to account for local influencing factor.
The new liquid-stable QCs from Canon Medical Diagnostics Corp. are an exciting innovation set to revolutionise FIT laboratory workflows and reduce pre-analytical variability:
Liquid formulation
Store in the fridge (2-8°C)
Open vial stability until stated expiration date
Packs contain easy-to-use 3ml dropper bottles (2 x high, 2 x low)
Assigned value range of ±8% for high and ±10% for low concentrations
Simply bring to room temperature before use and gently squeeze 5 drops per level into each sample cup.
The introduction of liquid QCs offers new benefits whilst giving additional options for the laboratory to utilise the FIT QC solution most appropriate for their workload and workflows.
Small volume labs may opt to use the lyophilised QCs due to the increased shelf-life and economical option to utilise small aliquots of reconstituted solution, whereas high volume labs may opt for liquid QCs to reduce initial start-up time ahead of large batches.
Lyophilised QCs
Liquid QCs
Product Code
065557
066096
Pack Size
8 x 1ml (4 x high, 4 x low)
4 x 3ml (2 x high, 2 x low)
Manufacturer’s shelf-life
20 months from date of manufacture
12 months from date of manufacture
Pre-use storage
2 to 8°C
2 to 8°C
Post-use storage
1ml aliquots can be stored in the freezer at -30°C
2 to 8°C
Usage
200µl per level
5 drops per level
Open vial stability
1ml aliquots stored in the freezer at -30°C for up to one month.
Until stated expiry on pack
Whatever your FIT requirements are, Alpha Laboratories is on-hand to help each step of the way.
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